386 The Adaptive Response of Old ABCB5+ MSCs is Changed Upon Exposure to LPS
نویسندگان
چکیده
Mesenchymal stem cells (MSCs) are endowed with the unique capacity to raise an adaptive response environmental cues. This allows MSCs control their direct neighbourhood and endogenous tissue niche. Upon exposure of infection mimicking lipopolysaccharide (LPS), completely shift transcriptome release neutrophil activating chemokines. The LPS induced transcriptomic resulted in a significant increase expulsed DNA traps (NETs) proteolytic enzymes. guarantees defense from bacterial attack. Wound healing decreases age propensity for increases. Therefore, we addressed question whether old healthy donors (> 65 years) unlike young (< 30 may change upon towards reduced microbicidal response. Cultured ABCB5+ treated revealed differences time kinetic NF-κB translocation cytoplasm nucleus. By contrast donors, depicted significantly delayed back regulation nuclear translocation, supported by overshooting p-p65. correlates higher longer persisting expression target genes like IL-6 elderly individuals compared individuals. Notably, depict levels IL-8 IL-10 donors. Of note, primed can activate neutrophils producing NETs level comparison NE activity indicative NET formation co-cultures MSC PMA stimulated is LPS-concentration-dependent Collectively, reveal dysregulated anti-bacterial which impressively killing ability gram negative bacteria at least part explained susceptibility severe infections elderly.
منابع مشابه
“Not Everything That Is Faced Can Be Changed, but Nothing Can Be Changed Until It Is Faced”: A Response to Recent Commentaries
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2022
ISSN: ['1523-1747', '0022-202X']
DOI: https://doi.org/10.1016/j.jid.2022.09.399